Abstract: Purpose : To investigate the expression of f ragile histidine t riad(FHIT) and p53 in gast ric carcinoma ( GC) and their relationship to clinicopathological factors. Methods : Seventy2eight cases of GC were studied using immunohistochemical technigue. Results : The positive rates of FHIT and p53 gene expression were 43. 6 % and 52. 6 % respectively. No correlation was found between the FHIT and p53 expression and their clinico2 pathological factors such as histological type , lymph node metastasis and staging. Conclusion : ①Loss of FHIT expression is a f requent event in GC and FHIT gene may be one of the important candidate tumor suppressor gene in carcinogenesis of GC; ②Detection of FHIT and p53 expression in biopsy specimens might be useful inscreening of high2risk population.

Key words: Gastric carcinoma, fragile histidine triad, p53